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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

17 million
people experience early AMD1

Here's how B vitamins and AREDS2 nutrients can help support them.

22%

lower risk of neovascular AMD8

25%
risk reduction in moderate-to-advanced AMD7
B Vitamins

Support cellular metabolism and healthy homocysteine levels2*

AREDS2 Nutrients

NEI-recommended nutrients help reduce the
risk of AMD progression5,6*†

Supports
the body’s natural response to oxidative stress2*

42%

reduced risk of early AMD4

41%

reduced risk of visually significant AMD3

B Vitamins

Support cellular metabolism and healthy homocysteine levels2*

41%

reduced risk of visually
significant AMD3

42%

reduced risk of early AMD4

B Vitamins +
AREDS2 Nutrients

Supports the body’s natural response to oxidative stress2*

AREDS2 Nutrients

NEI-recommended nutrients help reduce the risk of AMD progression5,6*†

25%

risk reduction in moderate-to-advanced AMD7

22%

lower risk of neovascular AMD8

Evidence suggests that B vitamins and AREDS2 nutrients both support macular health and help reduce the risk of progression of AMD. B vitamins support cellular metabolism and help maintain healthy homocysteine levels2*. They are associated with a 41% reduced risk of visually significant AMD3 and a 42% reduced risk of early AMD4. AREDS2 NEI-recommended nutrients help reduce the risk of AMD progression5,6†, including a 25% risk reduction in moderate-to-advanced AMD7 and a 22% lower risk of neovascular AMD8. B vitamins and AREDS2 nutrients support the body’s natural response to oxidative stress2*.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

†In moderate-to-advanced AMD patients.

Multiple Studies Support the Role
of
B Vitamins in Reducing Incidence
and
Progression
of AMD

These study outcomes helped inform the ingredient profile for the PreserVision AREDS3 Eye Vitamin & Mineral Supplement formulation:*

Nutrient
Dietary Intake
Risk Level
B1
↑
↓ by ~45-60%9 for late AMD
B6
↑
↓ for wet AMD10
B9
↑
↓ for developing GA and
large drusen10,4
B12
↑
↓ for AMD by 42%4
B5, B6
↑
↓ by ~28% for advanced AMD4
B6, B9
↑
↓ for late AMD10
B1, B2, B3, B5,
B6, B9, B12**
↓
Observed in patients with
AMD vs without AMD11,12
Daily Supplement
B2 + 13 other ingredients
Stabilized
atrophic AMD13,14
B3 + 2 other ingredients
Improved a measure of retinal function (FERG)15
B12 + 11 other ingredients
Functional improvement
of preganglionic
retinal elements16
B6, B9, B12
↓ risk of AMD vs
placebo by ~41%3
Nutrient
B1
Dietary Intake: ↑
Risk Level: ↓ by ~45-60%9 for late AMD
B6
Dietary Intake: ↑
Risk Level: ↓ for wet AMD10
B9
Dietary Intake: ↑
Risk Level: ↓ for developing GA and large drusen10,4
B12
Dietary Intake: ↑
Risk Level: ↓ for AMD by 42%4
B5, B6
Dietary Intake: ↑
Risk Level: ↓ by ~28% for advanced AMD4
B6, B9
Dietary Intake: ↑
Risk Level: ↓ for late AMD10
B1, B2, B3, B5, B6, B9, B12**
Dietary Intake: ↓
Risk Level: Observed in patients with AMD vs without AMD11,12
Daily Supplement
B2 + 13 other ingredients
Stabilized atrophic AMD13,14
B3 + 2 other ingredients
Improved a measure of retinal function (FERG)15
B12 + 11 other ingredients
Functional improvement of preganglionic retinal elements16
B6, B9, B12
↓ risk of AMD vs placebo by ~41%3

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

An upward arrow (↑) indicates increased dietary intake or higher nutrient levels, while a downward arrow (↓) indicates a reduction in risk, incidence, or progression of AMD.
**A downward arrow (↓) indicates a decreased intake of these nutrients was observed in patients with AMD vs without AMD.

Select B-vitamin supplementation may
help reduce
homocysteine,
a
modifiable AMD risk factor3

The PreserVision AREDS3 Eye Vitamin & Mineral Supplement Formulation

Our next-gen formula combines AREDS2 nutrients with a
B-vitamin complex.

Nutrient
AREDS2
PreserVision AREDS3 Eye Vitamin
Lutein
10 mg
10 mg
Zeaxanthin
2 mg
2 mg
Vitamin C
500 mg
500 mg
Vitamin E
180 mg
180 mg
Zinc
80 mg
25 mg
Copper
2 mg
2 mg
Thiamin (Vitamin B1)
—
3.6 mg
Riboflavin (Vitamin B2)
—
3.9 mg
Niacin (Vitamin B3)
—
32 mg
Pantothenic Acid (Vitamin B5)
—
15 mg
Vitamin B6
—
50 mg
Biotin (Vitamin B7)
—
90 mcg
Folate (Vitamin B9)
—
1500 mcg DFE
(900 mcg folic acid)
Vitamin B12
—
1000 mcg
areds3_icon1

PreserVision AREDS3 Eye Vitamins retain the same evidence-based nutrients of AREDS2: vitamin C, vitamin E, lutein, zeaxanthin, copper, and zinc*

areds3_icon1

B vitamins were added to the formula for potential metabolic support: homocysteine homeostasis, mitochondrial function, and vascular health*

areds3_icon1

Take 1 Soft Gel with a meal
2 times per day

Nutrient
Lutein
AREDS2: 10 mg
AREDS3: 10 mg
Zeaxanthin
AREDS2: 2 mg
AREDS3: 2 mg
Vitamin C
AREDS2: 500 mg
AREDS3: 500 mg
Vitamin E
AREDS2: 180 mg
AREDS3: 180 mg
Zinc
AREDS2: 80 mg
AREDS3: 25 mg
Copper
AREDS2: 2 mg
AREDS3: 2 mg
Thiamin (Vitamin B1)
AREDS2: —
AREDS3: 3.6 mg
Riboflavin (Vitamin B2)
AREDS2: —
AREDS3: 3.9 mg
Niacin (Vitamin B3)
AREDS2: —
AREDS3: 32 mg
Pantothenic Acid (Vitamin B5)
AREDS2: —
AREDS3: 15 mg
Vitamin B6
AREDS2: —
AREDS3: 50 mg
Biotin (Vitamin B7)
AREDS2: —
AREDS3: 90 mcg
Folate (Vitamin B9)
AREDS2: —
AREDS3: 1500 mcg DFE
(900 mcg folic acid)
Vitamin B12
AREDS2: —
AREDS3: 1000 mcg
areds3_icon1

PreserVision AREDS3 Eye Vitamins retain the same
evidence-based nutrients of
AREDS2: vitamin C, vitamin E,
lutein, zeaxanthin, copper, and
zinc*

areds3_icon1

B vitamins were added to the
formula for potential metabolic
support: homocysteine homeostasis,
mitochondrial function, and
vascular health*

areds3_icon1

Take 1 Soft Gel with a meal
2 times per day

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Review the Latest
Article on
the Role of B Vitamins
in AMD Progression:

Click Here

AMD = age-related macular degeneration
AREDS = age-related eye disease study
NEI = National Eye Institute

REFERENCES: 1. Circana. Bausch + Lomb Consumer Data Science. Total US panel L52WE Oct 5, 2025. IQVIA. Bausch + Lomb Consumer Data Science. Total US study—size of AMD. November 2024. 2. Poteet J et al. Ophthalmol Ther. 2025. 3. Christen WG et al. Arch Intern Med. 2009;169:335-341. 4. Merle BMJ et al. Nutrients. 2022;14(14):2821. 5. Age-Related Eye Disease Study Research Group. Arch Ophthalmol. 2001;119(10):1417-1436. 6. Chew EY et al. Ophthalmology. 2012;119(11):2282-2289. 7. Chew EY et al. JAMA Ophthalmol. 2022;140(7):692-698. 8. Age-Related Eye Disease Study 2 (AREDS2) Research Group. JAMA. 2013;309(19):2005-2015. 9. Zheng Q et al. Ophthalmic Res. 2023;66:1353-1361. 10. Agrón E et al. Ophthalmology. 2021;128:425-442. 11. Šalková Kráľová J et al. Cent Eur J Public Health. 2023;31:140-143. 12. Liu Z et al. Front Nutr. 2024;11:1504081. 13. Age-Related Macular Degeneration Study Group. J Am Optom Assoc. 1996;67:12-29. 14. Richer S. J Am Optom Assoc. 1996;67:30-49. 15. Falsini B et al. Ophthalmology. 2003;110:51-60. 16. Parravano M et al. Adv Ther. 2019;36:2493-2505.

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